Andrew Huberman interviews Dr. David Spiegel about hypnosis as a state of highly focused attention that can enhance control over mind and body rather than diminish it. They discuss the underlying brain networks involved in hypnosis, including changes in the dorsal anterior cingulate cortex, dorsolateral prefrontal cortex, insula, and posterior cingulate cortex, and how these changes support dissociation, cognitive flexibility, and altered bodily control. The conversation covers clinical applications such as stress reduction, sleep, pain management, phobias, trauma and PTSD treatment, hypnotizability assessment, the eye‑roll test, the role of breathing, and how hypnotic-like states show up in performance, children, and group settings.
Stephen speaks with technology ethicist Tristan Harris about how incentives in the tech industry led from social media harms to a new wave of powerful AI systems, and why current AI development is on a trajectory most people would not choose if they saw it clearly. Tristan explains the race toward artificial general intelligence (AGI), the private beliefs and fears of AI leaders, the likely impacts on jobs, politics, and social fabric, and the emerging risks from AI companions and therapy bots. They conclude by outlining potential governance, design, and civic responses that could steer AI onto a narrower, safer path if enough people act in time.
Theo Von records a Thanksgiving-themed solo episode with producer Riley Mao, reflecting on the holiday, American history, the current state of the world, and the importance of focusing on tangible relationships and small joys. He shares a humorous yet sincere list of little life experiences he appreciates, updates listeners on recent charity efforts, and reacts to several heartfelt listener calls about mental health, painful family dynamics, impending parenthood, and spiritual questions. Throughout, he and Riley also discuss Riley's upcoming fatherhood, Theo's evolving sense of purpose, and his desire to deepen his relationship with God and better care for himself.
Mel Robbins interviews psychotherapist and author Lori Gottlieb about how the stories people tell themselves shape their emotions, relationships, and life choices. They explore how these often-unconscious narratives are formed, how they keep people stuck in patterns like self-doubt, anxiety, and people-pleasing, and how to begin editing and rewriting them. Through concrete examples and practical questions, Lori shows how changing your story can change how you relate to yourself and others.
The host and guest discuss the concept of the predictive brain, explaining that the brain is not primarily a reactive organ but a prediction engine that prepares actions and experiences based on past learning. Using concrete examples such as language processing, thirst, coffee habits, exercise, trauma, and phobias, they show how prediction shapes perception, emotion, and bodily regulation. They also explore cultural inheritance, meaning-making, identity, and practical ways to change entrenched patterns by creating new experiences and dosing oneself with prediction error.
In this Advice Line episode of How I Built This Lab, host Guy Raz and Squarespace founder and CEO Anthony Casalena answer questions from three early-stage founders. They first discuss how Squarespace has evolved, including its role in a changing AI-driven web and its AI-enabled features. Then they advise a custom mattress entrepreneur, a clean first-aid brand founder, and the creator of an eating-disorder recovery app on branding, distribution, go-to-market strategies, and leveraging early users, before Anthony shares a key retrospective lesson on following his gut faster.
Mel Robbins interviews gerontologist Dr. Carl Pillemer about the practical life lessons, regrets, and advice he gathered from people in their 80s, 90s, and 100s through his Legacy Project at Cornell. Drawing on hundreds of in-depth interviews, he shares elders' guidance on worry, relationships, work, health, choosing a partner, self-acceptance, and learning to be "happy in spite of" difficult circumstances. The conversation emphasizes acting now on what truly matters, because almost every very old person reports that life feels shockingly short in retrospect.
The hosts open with light banter about facials, manicures, and self-care before welcoming actor Claire Danes, who talks about her relatively low-key beauty routine, life in a New York City brownstone, and becoming a mother of three after an unexpected pregnancy at 44. She describes growing up in an artist loft in Soho, starting acting as a child, the whirlwind of early fame from "My So-Called Life" and "Romeo + Juliet," and how therapy and family grounded her. Danes also shares how she researches roles-including observing brain surgery and visiting Langley-her experiences on "Homeland," working with directors like Baz Luhrmann and Francis Ford Coppola, her eccentric family history (including an ancestor hanged in the Salem witch trials), and her new psychological thriller series "The Beast in Me" with Matthew Rhys.
Mel Robbins explains her "Let Them Theory" as a framework for handling difficult and emotionally immature people, especially within families, without losing your peace or power. She emphasizes that you cannot change other people, only your own responses, and that most adults behave like emotionally overwhelmed children when triggered. Through research-backed insights and concrete tools, she teaches how to accept people as they are, manage your own emotional reactions, set practical boundaries, and create healthier family dynamics.
Theo Von talks with streamer and content creator Sketch about the realities of live streaming, his recent experiences touring college football stadiums, and the mental and physical toll the lifestyle can take. They discuss relationships, shame, therapy, and faith, including how Sketch handled a highly publicized leaked video and how it changed his dating life. The conversation also covers college and pro football culture, future creative ambitions like reality TV and treasure-hunt style content, and various comedic riffs about health, doctors, sexuality, and identity.
Gabrielle Bernstein discusses Internal Family Systems (IFS) therapy and how it transformed her life, explaining the model of "parts" and the concept of Self as a calm, compassionate inner presence. She and the host explore how protector parts like anxiety, addiction, control, people-pleasing, and workaholism develop to guard against childhood pain, and how befriending rather than banishing them can reduce anxiety, overthinking, and people-pleasing. Gabrielle teaches a simple four-step daily check-in process, guides a live exercise, and shows how this work can improve self-judgment, relationships, parenting, boundaries, leadership, and self-forgiveness.
Hosts Ken Coleman and Jade Warshaw take live calls about career and money decisions, debt payoff, housing, cars, healthcare costs, and complicated family and relationship dynamics around finances. They emphasize trading short-term comfort for long-term peace, prioritizing debt freedom over investing or lifestyle upgrades, and facing the emotional and relational roots of money problems. The episode also covers broader themes like the affordability crisis in America, spending addictions, and how to structure money in second marriages.
The hosts examine the history, methods, and impact of conversion therapy, also known as reparative or ex-gay therapy, which claims to change a person's sexual orientation from gay to straight. They trace its roots from early pseudo-scientific psychological practices to its adoption by the Christian right as a major culture-war issue, and detail why the medical and psychological communities now condemn it as ineffective and harmful. The episode also covers specific abuse stories, research findings on mental health risks, legal efforts to ban conversion therapy for minors, and the movement's public unraveling through high-profile ex-gay leaders who later renounced it.
Dave Ramsey and Rachel Cruze take calls on money, careers, housing, medical debt, and family dynamics while emphasizing personal responsibility, peace of mind, and avoiding financial entanglements that create stress. They interview generosity content creator Jimmy Darts about his "Undercover Kindness" book and how small acts of giving transform both givers and receivers, and talk with Ramsey Personality Jade Warshaw about the emotional side of money and her journey out of heavy debt. The episode also features a couple celebrating paying off their home and becoming completely debt-free.
Harvard neuroscientist Dr. Jill Bolte-Taylor explains how four anatomically distinct brain systems shape our thoughts, emotions, and behavior, and argues that we can learn to consciously choose which "character" to lead with in any moment. She recounts her catastrophic left-hemisphere hemorrhagic stroke, eight-year recovery, and how losing her left brain radically shifted her perspective on identity, trauma, and the preciousness of life. Throughout the conversation she connects brain anatomy to practical tools for emotional regulation, trauma integration, lifestyle choices, and cultivating a more balanced, peaceful mind.
Tim Ferriss interviews Jack Canfield about his life, from a difficult childhood and early teaching career to becoming co-creator of the Chicken Soup for the Soul series and author of The Success Principles. Jack explains how mentorship from W. Clement Stone shaped his views on responsibility, goal setting, and success, and details the persistence and grassroots marketing that turned Chicken Soup for the Soul into a global phenomenon. He also discusses plant medicine experiences, limiting beliefs, decluttering "messes," aging, and why he is partly retiring to focus on family and creative hobbies.
In this live episode recorded at DAR Constitution Hall in Washington, D.C., therapist and author Laurie Gottlieb joins the host to unpack common relationship challenges around love, acceptance, communication, and vulnerability. They discuss why people feel they must "perform" to earn love, how to create true emotional safety, the difference between chemistry and compatibility, and how childhood patterns show up in adult conflicts. The conversation includes a live on-stage exercise with a couple from the audience and a Q&A addressing conflict timing, gift-giving stress, asking for attention, and relationships involving neurodivergence.
Host Shankar Vedantam talks with psychologist Stuart Ablon about why attempts to change others' behavior often fail when we assume the problem is a lack of motivation or willpower. Ablon explains how many challenging behaviors arise from lagging cognitive, emotional, and social skills, and describes his collaborative problem solving approach that emphasizes empathy, identifying unmet concerns, and jointly generating solutions. He illustrates the method with cases from psychiatric hospitals, juvenile detention, families, and workplaces, and discusses research showing it reduces challenging behavior and builds skills in both the people being helped and the helpers themselves.
Host Shankar Vedantam speaks with psychologist Antonio Pascual Leone about why breakups are so difficult, the emotional mistakes people commonly make when relationships end, and practical therapeutic tools such as structured grief lists, narrative reframing, letter writing, and empty-chair dialogues to help people process loss and create their own sense of closure. In the second half, cognitive scientist Phil Fernback discusses the illusion of knowledge-why we routinely overestimate how much we understand, how this affects domains like politics, medicine, and everyday decision-making, and how to cultivate greater intellectual humility and curiosity in conversations with others.
Jay Shetty interviews Judd Apatow about his life in comedy, from his early days as a teenage interviewer of stand‑up comics to creating influential films and television shows. Apatow describes learning to treat failure as part of the path to success, developing his voice as a writer and director, and navigating ego, rejection, and collaboration in Hollywood. He also talks about parenting, long‑term marriage, therapy, meditation, psychedelics, and the importance of kindness, mentorship, and doing work that feels meaningful rather than merely successful.
Jay Shetty interviews Malala about her journey from a mischievous schoolgirl in Pakistan to a globally recognized girls' education activist after surviving a Taliban assassination attempt at age 15. She describes the loss of her old life, the pressure of being turned into a global symbol, her struggles with loneliness, PTSD, and therapy, and the long process of reclaiming her own identity, humor, and desires. Malala also explains her ongoing work through Malala Fund, the situation of girls in places like Afghanistan, and how she navigated love, self-image, and marriage while staying committed to girls' education.
The hosts discuss OpenAI's new Sora app for AI-generated video, exploring its onboarding flow, social mechanics, and why it may be more powerful than TikTok as a multiplayer AI experience. They broaden the conversation to AI as a super app (including ChatGPT's Pulse), concerns about OpenAI's growing power, and how AI will reshape content creation, education, therapy, and addiction support. The episode also covers the rise of micro sports betting and prediction markets, new businesses tackling gambling addiction with AI, and the extreme personal data logging practices of Shopify CEO Tobi Lütke alongside their own approaches to life-logging and memory capture with tools like Meta smart glasses.
Comedian and actor Pete Davidson sits down for a long-form conversation about his life, from losing his firefighter father in the 9/11 attacks and how that shaped his childhood, to his struggles with depression, suicidality, addiction, and eventual decision to get sober. He discusses the emotional toll of fame and tabloid culture, his tendency toward self-sabotage and people-pleasing, and how therapy, recovery, and supportive relationships-especially with his mother and older comic friends-have helped him. Pete also talks about gearing up for his first international tour, reflecting on a previous Amish guest, and his excitement and fears around becoming a father for the first time.
Host Elise Hu introduces a favorite TED Talk by psychotherapist and author Lori Gottlieb, which explores how the stories people tell about their lives shape their experiences. Gottlieb explains that most problems reduce to themes of freedom and change, and she illustrates how reframing our narratives, considering other perspectives, and accepting responsibility can open up new possibilities for connection and growth.
Host Elise Hu introduces a replay of therapist and podcast host Esther Perel's TED talk, "Rethinking Infidelity, a talk for anyone who has ever loved." Perel examines why people cheat, including those in seemingly happy relationships, and how modern expectations of marriage intensify the impact of affairs. She explores the psychological meanings behind infidelity, the dual nature of betrayal and self-discovery, and offers ways couples can understand, heal from, and sometimes grow after an affair.
Theo Von talks with Louis C.K. about performing edgy stand-up in different kinds of venues, parenting, childhood neglect, race and taboo language, and the creative process behind Louis's novel "Ingram". They explore the American literary voice, the evolution of language, and broader cultural issues like polarization, social media addiction, and technology's physical footprint. A large part of the conversation centers on Louis's public downfall, his struggles with sex and pornography addiction, 12‑step recovery, and how confronting his own failures has reshaped his life, work, and friendship with Theo.
The conversation explores how common trauma is, how it affects brain function, and how eye movement desensitization and reprocessing (EMDR) can change traumatic responses. The guest explains specific brain regions involved in danger signaling, body awareness, and time perception, showing how trauma leads to chronic fear, loss of perspective, and reliving rather than remembering events. They then discuss EMDR's mechanisms, research evidence, and demonstrate a brief EMDR-style exercise that quickly reduces the host's emotional activation around a recent unpleasant experience.
The hosts speak with MIT Media Lab research scientist Natalia Kozmina about her study "Your brain on ChatGPT," which investigated how using large language models (LLMs) for essay writing affects brain activity, memory, and sense of ownership compared with using a search engine or no tools. They discuss her findings on reduced functional connectivity when using ChatGPT, more homogeneous writing, weaker recall, and diminished ownership, and explore broader implications for cognitive load, education, professional skills (such as medicine), mental health, AI companions, and the need for ethical guardrails and human‑focused research around AI and future brain‑computer interfaces.