#2420 - Chris Masterjohn
Joe Rogan speaks with nutrition researcher Chris Masterjohn about how mitochondrial function underlies many aspects of health, aging, and disease. They discuss topics including creatine for brain and muscle energy, red light and sunlight for mitochondrial support, cautious use of supplements such as methylene blue and CoQ10, the long-term risks of seed oils, and how exercise variety, skill training, and good nutrition can promote healthy longevity. The conversation also covers thyroid health, iodine and selenium, cholesterol and statins, and the potential role of nattokinase in reducing clot-related heart attack and stroke risk.
$10M Business ideas w/ The Most Interesting Guy In Tech
The hosts talk with investor and entrepreneur Shiel about housing affordability policies like a proposed 50-year mortgage, several AI-enabled business ideas for service industries, and health and longevity trends including peptides and EMS training. He shares his personal journey using surrogacy, the business opportunities and constraints in that space, and observations about prediction markets and San Francisco tech culture. They close with his contrarian view that most books are a waste of time compared to podcasts and his practice of emailing CEOs directly when brand experiences go wrong.
#835: Ben Patrick (KneesOverToesGuy) - 20-Minute Workouts That Produce Wild Results, From Chronic Knee Pain to Dunking Basketballs, Lessons from Charles Poliquin, Bulletproofing the Lower Body, and More
Tim Ferriss interviews strength coach Ben Patrick, also known as Knees Over Toes Guy, about his journey from debilitating knee pain and multiple surgeries to pain‑free athletic performance. Ben explains the origins of his knees‑over‑toes approach, the key exercises and minimalist programming he uses for joint health and performance, and how he applies this with clients and family, including his 71‑year‑old mother. They also discuss equipment innovations, American manufacturing, and Tim's philosophy on integrity, long‑term thinking, and resisting audience capture in media and business.
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman and Dr. David Sinclair discuss aging as a disease, the role of the epigenome and information loss in driving aging, and how these processes connect to visible signs of aging and age-related diseases. They explore how fasting, blood sugar control, growth hormone, amino acids like leucine, exercise, and compounds such as NMN influence key longevity pathways including sirtuins, mTOR, and NAD. The conversation also covers iron and senescent cells, biomarkers such as CRP and HbA1c, fertility and reproductive aging in animal models, and the broader concept that aspects of aging can potentially be slowed or partially reversed.
#833: Jack Canfield - Selling 600+ Million Books, Success Principles, and How He Made The 4-Hour Workweek Happen
Tim Ferriss interviews Jack Canfield about his life, from a difficult childhood and early teaching career to becoming co-creator of the Chicken Soup for the Soul series and author of The Success Principles. Jack explains how mentorship from W. Clement Stone shaped his views on responsibility, goal setting, and success, and details the persistence and grassroots marketing that turned Chicken Soup for the Soul into a global phenomenon. He also discusses plant medicine experiences, limiting beliefs, decluttering "messes," aging, and why he is partly retiring to focus on family and creative hobbies.
Improve Your Lymphatic System for Overall Health & Appearance
Andrew Huberman explains the structure and functions of the lymphatic system, how it interfaces with the blood circulatory system, and why it is essential for clearing cellular waste, supporting immunity, and maintaining healthy tissues. He explores how movement, breathing, sleep, and specific postures influence lymphatic and glymphatic (brain) clearance, and how impairments can contribute to issues like lymphedema, brain fog, and visible puffiness in the face. He also discusses links between exercise, cardiac lymphatic vessels, brain health, and how light exposure and gentle manual techniques can support lymphatic function and appearance.
Mayo Clinic Cancer Doctor: 5 Foods That Heal the Body, Starve Cancer, & Prevent Disease
Mel Robbins interviews double-board certified Mayo Clinic physician and integrative oncologist Dr. Dawn Musalem about how lifestyle choices like food, movement, sleep, stress, and love affect cancer risk and outcomes. Dr. Musalem shares research-backed guidance on cancer-fighting and cancer-promoting foods, the impact of exercise, fiber, and sleep on metabolic and cancer health, and why ultra-processed foods and certain additives increase disease risk. She also weaves in her personal story as a stage 4 cancer survivor and heart transplant recipient, offering perspective on acceptance, hope, and finding meaning after a life-changing diagnosis.
How to Overcome Inner Resistance | Steven Pressfield
Andrew Huberman interviews author Stephen Pressfield about his concept of resistance, the difference between amateurs and professionals, and the daily habits and mindsets that support sustained creative work. They discuss Pressfield's military and physical training background, his writing process and use of the "muse," his experiences with failure and delayed success, and broader topics such as calling, addiction, social media, mortality, competition, and life trade-offs in pursuing one's craft.
TECH005: What Tech Is Doing to Us with Justin Evidon (Tech Podcast)
Host Preston Pysh and guest Justin Evidon discuss how modern technology can be a double-edged sword, offering huge benefits while quietly reshaping behavior, privacy, and health. They cover social media recommendation algorithms, data sovereignty, decentralized protocols like Nostr, and emerging privacy-preserving AI tools. The conversation also explores physical impacts of technology such as LED light flicker, blue light, and electromagnetic exposure, along with practical strategies to protect circadian rhythms and use tech more intentionally.
Neil deGrasse Tyson: The Brutal Truth About Astrology! Our Breath Contains Molecules Jesus Inhaled!
Neil deGrasse Tyson discusses mortality, meaning, and the "cosmic perspective," arguing that humans are literally made of stardust and fundamentally connected to the universe and each other. He explores religion and spirituality, the evolution of belief, simulation theory, artificial intelligence, space travel and why Mars colonies are unlikely soon, as well as black holes, alien life, UFO claims, and why astrology and other untested beliefs can be dangerous when they replace objective truth. Throughout, he emphasizes scientific literacy, humility about what we know, and the importance of creating, rather than searching for, meaning in life.
Most Replayed Moment: The 7-Day Training Blueprint To Live Longer! Peter Attia
Peter Attia explains how he structures his weekly training to prioritize longevity, balancing resistance work, zone 2 cardio, and VO2 max training while minimizing injury risk. He details rep ranges for strength, hypertrophy, and endurance, his specific warm-up approach using dynamic neuromuscular stabilization and jumping, and why muscle mass, grip strength, and power are crucial for healthy aging. The conversation also covers glucose metabolism, the dangers of falls in older age, the role of the nervous system in flexibility, and a simple three-day resistance training split.