Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman and Dr. David Sinclair discuss aging as a disease, the role of the epigenome and information loss in driving aging, and how these processes connect to visible signs of aging and age-related diseases. They explore how fasting, blood sugar control, growth hormone, amino acids like leucine, exercise, and compounds such as NMN influence key longevity pathways including sirtuins, mTOR, and NAD. The conversation also covers iron and senescent cells, biomarkers such as CRP and HbA1c, fertility and reproductive aging in animal models, and the broader concept that aspects of aging can potentially be slowed or partially reversed.
Jay's Must-Listens: Are You Still Holding Onto Childhood Trauma? (Follow 3 Steps & FINALLY Heal) Ft. Gabor Mate & Oprah Winfrey
This episode is a curated collection of conversations about trauma, grief, and healing, featuring insights from Dr. Gabor Mate, John Legend, Oprah Winfrey, Dr. Bruce Perry, and Anita. Jay Shetty explores how trauma can be loud or subtle, why it often hides behind overachievement or people-pleasing, and how reframing the question from "What's wrong with me?" to "What happened to me?" opens the door to compassion and recovery. The guests share personal stories and frameworks on authenticity, grief, intergenerational wounds, and learning to live fully while carrying past pain.