Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi
Andrew Huberman and obstetrician-gynecologist Dr. Thais Aliabadi discuss how PCOS and endometriosis-two leading causes of infertility-are massively underdiagnosed and frequently dismissed as "normal" women's issues. They explain diagnostic criteria, underlying biology such as hypothalamic-pituitary-ovarian axis disruption and insulin resistance, and treatment options including lifestyle, supplements, medications, and surgery. They also cover egg count testing, egg freezing, endometriosis pain management, perimenopause and menopause symptoms, breast cancer lifetime risk assessment, and the need for women to actively advocate for their own health within a flawed medical system.
Insulin Doctor: This Is The First Sign Of Dementia! The Shocking Link Between Keto & Brain Decline!
Internal medicine physician and insulin-resistance specialist Dr. Annette Bosworth explains why she believes routinely generating ketones is central to preventing and reversing many chronic conditions. She discusses insulin's role in aging and disease, the practical steps of her "keto continuum" approach, measurement of glucose and ketones, and tools like sardine fasts and exogenous ketones to break through insulin resistance. She also shares case studies from her practice, the story of using a ketogenic diet alongside her mother's cancer care, and her own legal and political ordeal that tested her faith and resilience.
Most Replayed Moment: Calories In, Calories Out Is A Myth! Why Most Diets Fail - Dr. Jason Fung
The episode segment critiques the simplistic 'calories in, calories out' model of weight loss by explaining how the body adapts its basal metabolic rate to caloric restriction. The guest emphasizes the central role of hormones-especially insulin-in determining whether the body stores or burns fat, arguing that food is an instruction to the body, not just a source of calories. They discuss intermittent fasting, snacking patterns, exercise, and the concept of breakfast as tools or factors that influence hormonal balance and long-term weight regulation.
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman and Dr. David Sinclair discuss aging as a disease, the role of the epigenome and information loss in driving aging, and how these processes connect to visible signs of aging and age-related diseases. They explore how fasting, blood sugar control, growth hormone, amino acids like leucine, exercise, and compounds such as NMN influence key longevity pathways including sirtuins, mTOR, and NAD. The conversation also covers iron and senescent cells, biomarkers such as CRP and HbA1c, fertility and reproductive aging in animal models, and the broader concept that aspects of aging can potentially be slowed or partially reversed.
Women's Fertility & Lifestyle Debate: Dangers Of Not Having A Period! Fasting Can Backfire For Women
The host convenes four female health experts from exercise physiology, fertility, OB/GYN menopause care, and orthopedics to discuss women's hormonal health across the lifespan. They cover research bias against women, differences between male and female physiology, menstrual cycles as a vital sign, PCOS and endometriosis, contraception, fertility planning, perimenopause and menopause, and the role of lifestyle and hormone therapy in long-term health. Throughout, they emphasize that missing or irregular periods, chronic inflammation, and insulin resistance are early warning signs and that women can and should advocate for better-informed care.
Most Replayed Moment: The 7-Day Training Blueprint To Live Longer! Peter Attia
Peter Attia explains how he structures his weekly training to prioritize longevity, balancing resistance work, zone 2 cardio, and VO2 max training while minimizing injury risk. He details rep ranges for strength, hypertrophy, and endurance, his specific warm-up approach using dynamic neuromuscular stabilization and jumping, and why muscle mass, grip strength, and power are crucial for healthy aging. The conversation also covers glucose metabolism, the dangers of falls in older age, the role of the nervous system in flexibility, and a simple three-day resistance training split.
The Insulin & Heart Doctor: The Fastest Way To Burn Dangerous Visceral Fat. This is How Insulin Is Quietly Clotting Your Blood! - Dr Pradip Jamnadas
Cardiologist Pradip Jamnadas explains how modern lifestyles drive heart disease through insulin resistance, visceral fat, chronic inflammation, and hidden factors like gut dysfunction, toxins, and mold. He describes how fasting, time‑restricted eating, targeted exercise, and gut repair can reduce visceral fat, lower inflammation, improve vascular health, and rebalance the autonomic nervous system. The conversation also covers LDL particle quality, the limitations and side effects of statins, practical diet guidance, vagus nerve "hacks", and his personal reflections on mortality and living in the present moment.