Andrew Huberman and obstetrician-gynecologist Dr. Thais Aliabadi discuss how PCOS and endometriosis-two leading causes of infertility-are massively underdiagnosed and frequently dismissed as "normal" women's issues. They explain diagnostic criteria, underlying biology such as hypothalamic-pituitary-ovarian axis disruption and insulin resistance, and treatment options including lifestyle, supplements, medications, and surgery. They also cover egg count testing, egg freezing, endometriosis pain management, perimenopause and menopause symptoms, breast cancer lifetime risk assessment, and the need for women to actively advocate for their own health within a flawed medical system.
In this Advice Line episode of How I Built This Lab, host Guy Raz and Squarespace founder and CEO Anthony Casalena answer questions from three early-stage founders. They first discuss how Squarespace has evolved, including its role in a changing AI-driven web and its AI-enabled features. Then they advise a custom mattress entrepreneur, a clean first-aid brand founder, and the creator of an eating-disorder recovery app on branding, distribution, go-to-market strategies, and leveraging early users, before Anthony shares a key retrospective lesson on following his gut faster.
In this Advice Line episode of How I Built This Lab, host Guy Raz and Wayfair co-founder and CEO Neeraj Shah take calls from three founders seeking help with branding, financing, and career-risk decisions. They discuss how to clearly communicate a novel cooking ingredient (CookStix), when and how to seek funding for a mineral sunscreen brand (Daily Shade), and how a founder of a solo-women-travel housing app (HerHouse) should think about leaving a well-paid job. Neeraj also reflects on his long co-founder relationship, Wayfair's scale and focus strategy, and the non-linear nature of entrepreneurial journeys.
Host Jay Shetty speaks with physician and researcher Dr. Sara Szal about how hormones function as the body's messaging system, what hormonal imbalance looks like, and why stress and lifestyle are central drivers of issues like fatigue, weight gain, mood changes, and fertility challenges. They discuss cortisol, insulin, sex hormones, thyroid function, the impact of chronic stress and relationships, and practical ways to measure and rebalance hormones through testing, nutrition, sleep, stress management, and more informed choices about birth control. The conversation also covers life-stage hormone shifts, the risks and benefits of the birth control pill versus IUDs, natural family planning, and how integrating spirituality and self-awareness with medical science can prevent burnout and support healing.
The host and four women's health experts explore how female physiology, hormones, and life stages change the way women should approach exercise, nutrition, fasting, recovery, and sleep. They explain why most fitness and medical research based on men fails women, detail how the menstrual cycle and perimenopause affect training and metabolism, and outline practical protocols for strength training, cardio, bone health, and weight management. The conversation also addresses fertility, energy availability, environmental toxins, supplements, and the need for women to advocate for their own health throughout life.
Mel Robbins interviews double-board certified Mayo Clinic physician and integrative oncologist Dr. Dawn Musalem about how lifestyle choices like food, movement, sleep, stress, and love affect cancer risk and outcomes. Dr. Musalem shares research-backed guidance on cancer-fighting and cancer-promoting foods, the impact of exercise, fiber, and sleep on metabolic and cancer health, and why ultra-processed foods and certain additives increase disease risk. She also weaves in her personal story as a stage 4 cancer survivor and heart transplant recipient, offering perspective on acceptance, hope, and finding meaning after a life-changing diagnosis.
The conversation focuses on how everyday household, beauty, and personal care products can expose people to carcinogens and endocrine-disrupting chemicals, and how small, practical changes can significantly reduce that exposure. Dr Yvonne Burkart explains links between environmental chemicals and rising cancer incidence, especially breast cancer, and describes research showing that removing certain ingredients from products lowered breast cancer gene expression in just 28 days. She offers detailed guidance on identifying problematic ingredients like "fragrance" and phthalates in deodorants, candles, and incense, highlights children's particular vulnerability via contaminated household dust, and proposes safer alternatives such as essential-oil-based products and low-emission beeswax candles.
The host convenes four female health experts from exercise physiology, fertility, OB/GYN menopause care, and orthopedics to discuss women's hormonal health across the lifespan. They cover research bias against women, differences between male and female physiology, menstrual cycles as a vital sign, PCOS and endometriosis, contraception, fertility planning, perimenopause and menopause, and the role of lifestyle and hormone therapy in long-term health. Throughout, they emphasize that missing or irregular periods, chronic inflammation, and insulin resistance are early warning signs and that women can and should advocate for better-informed care.
Host Elise Hu introduces a TED 2025 talk by activist and content creator Deja Fox, who recounts how a viral confrontation with her senator over access to birth control thrust her into the public eye as a teenager. She describes both the opportunities and harms that came with online fame, including coordinated harassment and the absence of effective platform protections. Fox then highlights girl- and women-led digital collectives and platforms that prioritize safety, privacy, respect, and user ownership, calling for a "girl internet" and inviting listeners to help build a more equitable digital future.
Host Elise Hu interviews activist and digital strategist Deja Fox about how teen girls and young women are using social media and alternative online platforms to build power and community. Fox reflects on her viral confrontation with a senator over birth control access, her work on Kamala Harris's 2024 campaign, and her decision to run for Congress. They also discuss the gendered harms of current tech architecture, including AI-enabled deepfakes and digital violence, and what safer, more inclusive women-led online spaces could look like.