#2420 - Chris Masterjohn
Joe Rogan speaks with nutrition researcher Chris Masterjohn about how mitochondrial function underlies many aspects of health, aging, and disease. They discuss topics including creatine for brain and muscle energy, red light and sunlight for mitochondrial support, cautious use of supplements such as methylene blue and CoQ10, the long-term risks of seed oils, and how exercise variety, skill training, and good nutrition can promote healthy longevity. The conversation also covers thyroid health, iodine and selenium, cholesterol and statins, and the potential role of nattokinase in reducing clot-related heart attack and stroke risk.
Sunday Pick: How to use your muscles - or risk losing them | How to Be a Better Human
Host Chris Duffy talks with journalist and author Bonnie Tsui about what muscles really are, why they matter, and how strength training can transform health and identity across a lifetime. They discuss age-related muscle loss, the importance of lifting "heavy" for everyone, and how muscle functions as both mechanical mover and endocrine tissue that communicates with the brain. The conversation also explores gendered body norms, strong women in sport, Bonnie's upbringing with a martial-artist father, surfing as a metaphor for presence, and how interoception and muscle memory help us navigate injury, aging, and joy in movement.
Most Replayed Moment: Calories In, Calories Out Is A Myth! Why Most Diets Fail - Dr. Jason Fung
The episode segment critiques the simplistic 'calories in, calories out' model of weight loss by explaining how the body adapts its basal metabolic rate to caloric restriction. The guest emphasizes the central role of hormones-especially insulin-in determining whether the body stores or burns fat, arguing that food is an instruction to the body, not just a source of calories. They discuss intermittent fasting, snacking patterns, exercise, and the concept of breakfast as tools or factors that influence hormonal balance and long-term weight regulation.
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman and Dr. David Sinclair discuss aging as a disease, the role of the epigenome and information loss in driving aging, and how these processes connect to visible signs of aging and age-related diseases. They explore how fasting, blood sugar control, growth hormone, amino acids like leucine, exercise, and compounds such as NMN influence key longevity pathways including sirtuins, mTOR, and NAD. The conversation also covers iron and senescent cells, biomarkers such as CRP and HbA1c, fertility and reproductive aging in animal models, and the broader concept that aspects of aging can potentially be slowed or partially reversed.
Improve Your Lymphatic System for Overall Health & Appearance
Andrew Huberman explains the structure and functions of the lymphatic system, how it interfaces with the blood circulatory system, and why it is essential for clearing cellular waste, supporting immunity, and maintaining healthy tissues. He explores how movement, breathing, sleep, and specific postures influence lymphatic and glymphatic (brain) clearance, and how impairments can contribute to issues like lymphedema, brain fog, and visible puffiness in the face. He also discusses links between exercise, cardiac lymphatic vessels, brain health, and how light exposure and gentle manual techniques can support lymphatic function and appearance.
Longevity Debate: The Truth About Weight Loss, Muscle, and Creatine!
The host and four women's health experts explore how female physiology, hormones, and life stages change the way women should approach exercise, nutrition, fasting, recovery, and sleep. They explain why most fitness and medical research based on men fails women, detail how the menstrual cycle and perimenopause affect training and metabolism, and outline practical protocols for strength training, cardio, bone health, and weight management. The conversation also addresses fertility, energy availability, environmental toxins, supplements, and the need for women to advocate for their own health throughout life.
#620 - Keith Peterson
The host interviews MMA referee and longtime diesel mechanic Keith Peterson about his no-nonsense approach to officiating, his path from amateur fighter to top-level referee, and his life in New York hardcore music. Peterson describes his family life, long marriage, parenting three kids who are into music, wrestling, and skateboarding, and his commitment to coaching girls' wrestling alongside his daughter. He also discusses health changes, the loss of his brother, and the discipline and safety mindset required to referee high-stakes fights.
Advice Line with John Zimmer of Lyft
Host Guy Raz speaks with Lyft co-founder John Zimmer about his transition out of day-to-day leadership, the emotional and mental health challenges of stepping away, and his interest in building new, mission-driven consumer businesses. Together they take calls from three founders: a UK inventor of a soap-mixing showerhead seeking to scale to the U.S., a rucking gear entrepreneur struggling with inventory financing and tariffs, and a craft chocolate maker wrestling with work-life balance and long-term employee ownership. The episode focuses on practical advice around focus, financing, go-to-market tests, and personal sustainability for founders.
Mayo Clinic Cancer Doctor: 5 Foods That Heal the Body, Starve Cancer, & Prevent Disease
Mel Robbins interviews double-board certified Mayo Clinic physician and integrative oncologist Dr. Dawn Musalem about how lifestyle choices like food, movement, sleep, stress, and love affect cancer risk and outcomes. Dr. Musalem shares research-backed guidance on cancer-fighting and cancer-promoting foods, the impact of exercise, fiber, and sleep on metabolic and cancer health, and why ultra-processed foods and certain additives increase disease risk. She also weaves in her personal story as a stage 4 cancer survivor and heart transplant recipient, offering perspective on acceptance, hope, and finding meaning after a life-changing diagnosis.
Most Replayed Moment: The 7-Day Training Blueprint To Live Longer! Peter Attia
Peter Attia explains how he structures his weekly training to prioritize longevity, balancing resistance work, zone 2 cardio, and VO2 max training while minimizing injury risk. He details rep ranges for strength, hypertrophy, and endurance, his specific warm-up approach using dynamic neuromuscular stabilization and jumping, and why muscle mass, grip strength, and power are crucial for healthy aging. The conversation also covers glucose metabolism, the dangers of falls in older age, the role of the nervous system in flexibility, and a simple three-day resistance training split.
It's Not Too Late: How to Transform Your Life at Any Moment
Mel Robbins interviews Rich Roll about how he has radically transformed his life multiple times, from a bullied, approval-seeking kid to an alcoholic lawyer, then to a sober, plant-based ultra-endurance athlete and podcaster. Rich details his descent into severe alcoholism, his recovery, his midlife health crisis at 40, and the sequence of small, contrary actions that allowed him to change course. The conversation focuses on addiction as a spectrum, listening to "knocks" from the universe, prioritizing health, and using tiny consistent actions to change at any age.
#2389 - Sal Vulcano
Joe Rogan and Sal Vulcano talk about getting older, becoming parents, and reworking their lifestyles around health, training, and stand-up touring. They swap stories about humiliating youth sports experiences, dangerous stunts and punishments from Sal's show, brushes with possible ghosts, and the terror of the ocean and tsunamis. The conversation also ranges into archery and bowhunting, modern art and alleged CIA influence, UFO-like drone swarms, AI tools, and how energy, mindset, and the people you spend time with shape your life.
Inside WWE's storytelling machine | Paul "Triple H" Levesque
Paul "Triple H" Levesque discusses how WWE blends athleticism, storytelling, and character to create a unique form of entertainment that emotionally engages a massive global audience. In conversation with Patrick Talty, he explains WWE's creative process, media partnerships, and the importance of family, presence, and health, including his work on the President's Fitness Council. He also reflects on his own journey from childhood fan to performer to chief content officer, and how WWE's stories can inspire resilience and connection for fans around the world.
Build Your Ideal Physique | Dr. Bret Contreras
Andrew Huberman interviews strength scientist and coach Brett Contreras about how to build an ideal physique through evidence-based resistance training. They cover training frequency, volume, and progressive overload, how to structure full-body and split routines, and how to specialize to bring up lagging muscle groups, with a major focus on glute development. They also discuss recovery genetics, long-term sustainability, injury prevention, glute and calf techniques, training across the lifespan including perimenopause, menopause, and pregnancy, and how to use body recomposition instead of extreme bulking and cutting.
The Insulin & Heart Doctor: The Fastest Way To Burn Dangerous Visceral Fat. This is How Insulin Is Quietly Clotting Your Blood! - Dr Pradip Jamnadas
Cardiologist Pradip Jamnadas explains how modern lifestyles drive heart disease through insulin resistance, visceral fat, chronic inflammation, and hidden factors like gut dysfunction, toxins, and mold. He describes how fasting, time‑restricted eating, targeted exercise, and gut repair can reduce visceral fat, lower inflammation, improve vascular health, and rebalance the autonomic nervous system. The conversation also covers LDL particle quality, the limitations and side effects of statins, practical diet guidance, vagus nerve "hacks", and his personal reflections on mortality and living in the present moment.