Andrew Huberman interviews strength scientist and coach Brett Contreras about how to build an ideal physique through evidence-based resistance training. They cover training frequency, volume, and progressive overload, how to structure full-body and split routines, and how to specialize to bring up lagging muscle groups, with a major focus on glute development. They also discuss recovery genetics, long-term sustainability, injury prevention, glute and calf techniques, training across the lifespan including perimenopause, menopause, and pregnancy, and how to use body recomposition instead of extreme bulking and cutting.