Most Replayed Moment: Calories In, Calories Out Is A Myth! Why Most Diets Fail - Dr. Jason Fung
The episode segment critiques the simplistic 'calories in, calories out' model of weight loss by explaining how the body adapts its basal metabolic rate to caloric restriction. The guest emphasizes the central role of hormones-especially insulin-in determining whether the body stores or burns fat, arguing that food is an instruction to the body, not just a source of calories. They discuss intermittent fasting, snacking patterns, exercise, and the concept of breakfast as tools or factors that influence hormonal balance and long-term weight regulation.
Build Your Ideal Physique | Dr. Bret Contreras
Andrew Huberman interviews strength scientist and coach Brett Contreras about how to build an ideal physique through evidence-based resistance training. They cover training frequency, volume, and progressive overload, how to structure full-body and split routines, and how to specialize to bring up lagging muscle groups, with a major focus on glute development. They also discuss recovery genetics, long-term sustainability, injury prevention, glute and calf techniques, training across the lifespan including perimenopause, menopause, and pregnancy, and how to use body recomposition instead of extreme bulking and cutting.
The Spark of Life
Host Molly Webster speaks with applied biophysicist Narosha Murugan about the discovery that living cells emit extremely faint light tied to their metabolism, and explores how this challenges the traditional lock-and-key view of cellular signaling. They discuss possible mechanisms for how this light is generated in mitochondria and potentially guided through cellular structures, its hypothesized roles in brain function and consciousness, and how its distinct signatures can already be used experimentally to detect cancer and distinguish living from dead tissue. The conversation ends with reflections on "life flashes" at fertilization and death, and on thinking of living beings as organized patterns of energy and light.