#2420 - Chris Masterjohn
Joe Rogan speaks with nutrition researcher Chris Masterjohn about how mitochondrial function underlies many aspects of health, aging, and disease. They discuss topics including creatine for brain and muscle energy, red light and sunlight for mitochondrial support, cautious use of supplements such as methylene blue and CoQ10, the long-term risks of seed oils, and how exercise variety, skill training, and good nutrition can promote healthy longevity. The conversation also covers thyroid health, iodine and selenium, cholesterol and statins, and the potential role of nattokinase in reducing clot-related heart attack and stroke risk.
Most Replayed Moment: Calories In, Calories Out Is A Myth! Why Most Diets Fail - Dr. Jason Fung
The episode segment critiques the simplistic 'calories in, calories out' model of weight loss by explaining how the body adapts its basal metabolic rate to caloric restriction. The guest emphasizes the central role of hormones-especially insulin-in determining whether the body stores or burns fat, arguing that food is an instruction to the body, not just a source of calories. They discuss intermittent fasting, snacking patterns, exercise, and the concept of breakfast as tools or factors that influence hormonal balance and long-term weight regulation.
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman and Dr. David Sinclair discuss aging as a disease, the role of the epigenome and information loss in driving aging, and how these processes connect to visible signs of aging and age-related diseases. They explore how fasting, blood sugar control, growth hormone, amino acids like leucine, exercise, and compounds such as NMN influence key longevity pathways including sirtuins, mTOR, and NAD. The conversation also covers iron and senescent cells, biomarkers such as CRP and HbA1c, fertility and reproductive aging in animal models, and the broader concept that aspects of aging can potentially be slowed or partially reversed.
Dr. Sara Szal: Stop Ignoring What Your Body's Trying to Tell You! (THESE Are the Hormone Signals You Can't Afford to Miss!
Host Jay Shetty speaks with physician and researcher Dr. Sara Szal about how hormones function as the body's messaging system, what hormonal imbalance looks like, and why stress and lifestyle are central drivers of issues like fatigue, weight gain, mood changes, and fertility challenges. They discuss cortisol, insulin, sex hormones, thyroid function, the impact of chronic stress and relationships, and practical ways to measure and rebalance hormones through testing, nutrition, sleep, stress management, and more informed choices about birth control. The conversation also covers life-stage hormone shifts, the risks and benefits of the birth control pill versus IUDs, natural family planning, and how integrating spirituality and self-awareness with medical science can prevent burnout and support healing.
Women's Fertility & Lifestyle Debate: Dangers Of Not Having A Period! Fasting Can Backfire For Women
The host convenes four female health experts from exercise physiology, fertility, OB/GYN menopause care, and orthopedics to discuss women's hormonal health across the lifespan. They cover research bias against women, differences between male and female physiology, menstrual cycles as a vital sign, PCOS and endometriosis, contraception, fertility planning, perimenopause and menopause, and the role of lifestyle and hormone therapy in long-term health. Throughout, they emphasize that missing or irregular periods, chronic inflammation, and insulin resistance are early warning signs and that women can and should advocate for better-informed care.