Joe Rogan speaks with nutrition researcher Chris Masterjohn about how mitochondrial function underlies many aspects of health, aging, and disease. They discuss topics including creatine for brain and muscle energy, red light and sunlight for mitochondrial support, cautious use of supplements such as methylene blue and CoQ10, the long-term risks of seed oils, and how exercise variety, skill training, and good nutrition can promote healthy longevity. The conversation also covers thyroid health, iodine and selenium, cholesterol and statins, and the potential role of nattokinase in reducing clot-related heart attack and stroke risk.
The hosts explore the history and cultural impact of Pop-Tarts, tracing their origins from the Kellogg brothers' Battle Creek Sanitarium through the cereal wars between Kellogg's and Post to the invention of the toaster pastry. They detail how Pop-Tarts were rapidly developed in response to a competitor's idea, how the product evolved in flavor, form, and marketing, and how it became an iconic but nutritionally dubious, ultra-processed food. The episode also covers fire hazards, lawsuits, international ingredient differences, and the nostalgic pull Pop-Tarts still have for adults.
Mel Robbins interviews double-board certified Mayo Clinic physician and integrative oncologist Dr. Dawn Musalem about how lifestyle choices like food, movement, sleep, stress, and love affect cancer risk and outcomes. Dr. Musalem shares research-backed guidance on cancer-fighting and cancer-promoting foods, the impact of exercise, fiber, and sleep on metabolic and cancer health, and why ultra-processed foods and certain additives increase disease risk. She also weaves in her personal story as a stage 4 cancer survivor and heart transplant recipient, offering perspective on acceptance, hope, and finding meaning after a life-changing diagnosis.
Dr. Robert Lustig explains how dopamine-driven behaviors and ultra-processed food, especially sugar, can create a "hostage brain" by rewiring reward pathways and degrading metabolic and brain health. He details mechanisms linking sugar, artificial sweeteners, mitochondrial dysfunction, and reactive oxygen species to Alzheimer's, cancer, depression, and other chronic diseases, while contrasting environmental versus genetic risk. The conversation also covers GLP-1 weight-loss drugs, vaccines and public health communication, loneliness, serotonin and oxytocin, practical strategies to reduce sugar and ultra-processed food, and emerging research on psychedelics and brain rewiring.
Cardiologist Pradip Jamnadas explains how modern lifestyles drive heart disease through insulin resistance, visceral fat, chronic inflammation, and hidden factors like gut dysfunction, toxins, and mold. He describes how fasting, time‑restricted eating, targeted exercise, and gut repair can reduce visceral fat, lower inflammation, improve vascular health, and rebalance the autonomic nervous system. The conversation also covers LDL particle quality, the limitations and side effects of statins, practical diet guidance, vagus nerve "hacks", and his personal reflections on mortality and living in the present moment.