$10M Business ideas w/ The Most Interesting Guy In Tech
The hosts talk with investor and entrepreneur Shiel about housing affordability policies like a proposed 50-year mortgage, several AI-enabled business ideas for service industries, and health and longevity trends including peptides and EMS training. He shares his personal journey using surrogacy, the business opportunities and constraints in that space, and observations about prediction markets and San Francisco tech culture. They close with his contrarian view that most books are a waste of time compared to podcasts and his practice of emailing CEOs directly when brand experiences go wrong.
X's Foreign Trolls, Google's AI Wins, and MTG's Resignation
Hosts Kara Swisher and Scott Galloway discuss foreign-operated troll accounts on X, broader Russian and other foreign influence operations on U.S. politics, and the GOP's shifting stance on Russia, including Marco Rubio's role in a controversial Ukraine peace plan. They analyze Google's new Gemini 3 model and Alphabet's AI strategy versus OpenAI, evaluate market jitters around the AI boom and crypto, and cover Marjorie Taylor Greene's announced resignation, Eli Lilly's GLP-1-fueled valuation, elite wealth and political power, and the importance of competent public servants and everyday gratitude practices.
Female Hormone Health, PCOS, Endometriosis, Fertility & Breast Cancer | Dr. Thaïs Aliabadi
Andrew Huberman and obstetrician-gynecologist Dr. Thais Aliabadi discuss how PCOS and endometriosis-two leading causes of infertility-are massively underdiagnosed and frequently dismissed as "normal" women's issues. They explain diagnostic criteria, underlying biology such as hypothalamic-pituitary-ovarian axis disruption and insulin resistance, and treatment options including lifestyle, supplements, medications, and surgery. They also cover egg count testing, egg freezing, endometriosis pain management, perimenopause and menopause symptoms, breast cancer lifetime risk assessment, and the need for women to actively advocate for their own health within a flawed medical system.
Insulin Doctor: This Is The First Sign Of Dementia! The Shocking Link Between Keto & Brain Decline!
Internal medicine physician and insulin-resistance specialist Dr. Annette Bosworth explains why she believes routinely generating ketones is central to preventing and reversing many chronic conditions. She discusses insulin's role in aging and disease, the practical steps of her "keto continuum" approach, measurement of glucose and ketones, and tools like sardine fasts and exogenous ketones to break through insulin resistance. She also shares case studies from her practice, the story of using a ketogenic diet alongside her mother's cancer care, and her own legal and political ordeal that tested her faith and resilience.
Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David Fajgenbaum
Andrew Huberman interviews physician-scientist Dr. David Fagenbaum about how many existing FDA-approved drugs can be repurposed to effectively treat diseases beyond their original indications. Drawing on his near-fatal battle with Castleman disease and the work of his nonprofit Every Cure, Fagenbaum explains systemic blind spots in medicine, gives concrete examples of successful drug repurposing, and outlines how patients can better advocate for themselves and navigate disease-specific networks. They also discuss the role of AI in mapping drug-disease relationships at scale, the neuroscience of hope and tenacity, and how Fagenbaum's personal story shapes his mission to ensure that no one misses out on a helpful drug that already exists.
Longevity Debate: The Truth About Weight Loss, Muscle, and Creatine!
The host and four women's health experts explore how female physiology, hormones, and life stages change the way women should approach exercise, nutrition, fasting, recovery, and sleep. They explain why most fitness and medical research based on men fails women, detail how the menstrual cycle and perimenopause affect training and metabolism, and outline practical protocols for strength training, cardio, bone health, and weight management. The conversation also addresses fertility, energy availability, environmental toxins, supplements, and the need for women to advocate for their own health throughout life.
Colleges Push Back, Ozempic Price Promise, and White House vs. Anthropic
Kara Swisher and Scott Galloway open with personal banter about Las Vegas, aging, relationships, and Kara's upcoming trip to Korea to film a show about demographic aging. They then discuss the nationwide No Kings protests against Trump, the Trump administration's proposed Compact for Academic Excellence and universities' coordinated pushback, and the White House's conflict with Anthropic over AI regulation amid broader concerns about regulatory capture by big tech. The hosts also cover GLP-1 drugs like Ozempic and Trump's claim about cutting their price, a major Chinese-linked cyberattack on F5 and U.S. infrastructure vulnerabilities, the externalities of AI data centers, and wins and fails including the protests, George Santos' commuted sentence, and debates over billionaire influence and philanthropy.
No. 1 Sugar Expert: 17 Seconds Of Pleasure Can Rewire Your Brain!
Dr. Robert Lustig explains how dopamine-driven behaviors and ultra-processed food, especially sugar, can create a "hostage brain" by rewiring reward pathways and degrading metabolic and brain health. He details mechanisms linking sugar, artificial sweeteners, mitochondrial dysfunction, and reactive oxygen species to Alzheimer's, cancer, depression, and other chronic diseases, while contrasting environmental versus genetic risk. The conversation also covers GLP-1 weight-loss drugs, vaccines and public health communication, loneliness, serotonin and oxytocin, practical strategies to reduce sugar and ultra-processed food, and emerging research on psychedelics and brain rewiring.