We're doing AI all wrong. Here's how to get it right | Sasha Luccioni
AI sustainability expert Sasha Luccioni argues that current AI development is being driven by a "bigger is better" mentality that concentrates power in a few large tech companies while causing significant environmental and social harms. She contrasts massive, energy-hungry large language models and data centers with smaller, task-specific and open AI systems that can run on modest hardware and support climate solutions. Luccioni calls for transparent energy metrics, supportive regulation, and user choices that prioritize sustainable, equitable AI that serves all of humanity and the planet.
Colleges Push Back, Ozempic Price Promise, and White House vs. Anthropic
Kara Swisher and Scott Galloway open with personal banter about Las Vegas, aging, relationships, and Kara's upcoming trip to Korea to film a show about demographic aging. They then discuss the nationwide No Kings protests against Trump, the Trump administration's proposed Compact for Academic Excellence and universities' coordinated pushback, and the White House's conflict with Anthropic over AI regulation amid broader concerns about regulatory capture by big tech. The hosts also cover GLP-1 drugs like Ozempic and Trump's claim about cutting their price, a major Chinese-linked cyberattack on F5 and U.S. infrastructure vulnerabilities, the externalities of AI data centers, and wins and fails including the protests, George Santos' commuted sentence, and debates over billionaire influence and philanthropy.
The new era of AI-powered protein design | César Ramírez-Sarmiento
Host Elise Hu introduces TED Fellow and protein engineer César Ramírez-Sarmiento, whose lab in Santiago, Chile uses artificial intelligence to design novel proteins for environmental and therapeutic applications. In his talk and follow-up conversation with TED Fellows Program Director Lily James-Olds, César explains what proteins are, how AI has radically improved protein design success rates, and how enzymes could help address challenges like plastic pollution, mining impacts, and climate change. They also discuss the dual-use risks of AI in biodesign, emerging global regulation and leadership (including Chile and other countries), and how César's artistic background shapes his creative approach to science and public communication.
TECH004: Sam Altman & the Rise of OpenAI w/ Seb Bunney
Host Preston Pysh and guest Seb Bunney discuss Karen Howe's book "Empire of AI: Dreams and Nightmares of Sam Altman's OpenAI," using it as a springboard to explore Sam Altman's biography, the founding and evolution of OpenAI, and the opaque 2023 boardroom crisis that briefly ousted Altman. They examine OpenAI's unusual nonprofit/for‑profit hybrid structure, its partnership with Microsoft, tensions between AI safety and competitive speed, and the hidden labor and economic costs of training large AI models. The conversation also touches on AGI definitions, human-AI interaction, other labs like Anthropic and DeepMind, NVIDIA's role in AI, and briefly previews their next book on longevity.
OpenAI Backtracks, Elon's Netflix Boycott, and Instagram Safety Features
Kara Swisher and Scott Galloway discuss U.S. immigration crackdowns under President Trump, including National Guard deployments, ICE raids, and the use of masked agents, arguing these tactics are authoritarian and designed to inflame division. They examine how tech platforms and algorithms amplify rage, debate OpenAI's Sora copyright policy and its impact on Hollywood and creative workers, and analyze Elon Musk's call to boycott Netflix, SpaceX's Chinese funding, and SpaceX's growing power in satellite-based mobile service. The episode also covers Instagram's inadequate teen safety measures, the mental health impact of social media on youth, and a Trump-era higher education compact that would reshape university admissions, ideology on campus, foreign enrollment, and pricing.
Saudi Comedy Festival Controversy, Threads' Major Milestone, and Trump's Movie Tariff
Kara Swisher and Scott Galloway discuss Donald Trump's proposed 100% tariff on movies made outside the U.S., arguing it would damage Netflix, Hollywood, and global content arbitrage, and then pivot to the Saudi state-backed Riyadh Comedy Festival, criticizing free-speech-branded comedians who accepted contracts barring criticism of the kingdom and religion. They examine consumer backlash that forced Sinclair and Nexstar to restore Jimmy Kimmel, Threads surpassing X in daily active users and changing media consumption habits, Trump's pressure-driven TikTok divestment plan that advantages major donors, his retribution-focused indictment of James Comey, the economic stupidity of tariffs and farm bailouts, and close with wins and fails plus a brief call for tighter limits on AI products for children.