Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body | Dr. David Fajgenbaum
Andrew Huberman interviews physician-scientist Dr. David Fagenbaum about how many existing FDA-approved drugs can be repurposed to effectively treat diseases beyond their original indications. Drawing on his near-fatal battle with Castleman disease and the work of his nonprofit Every Cure, Fagenbaum explains systemic blind spots in medicine, gives concrete examples of successful drug repurposing, and outlines how patients can better advocate for themselves and navigate disease-specific networks. They also discuss the role of AI in mapping drug-disease relationships at scale, the neuroscience of hope and tenacity, and how Fagenbaum's personal story shapes his mission to ensure that no one misses out on a helpful drug that already exists.
Celebrity Nutritionist Mona Sharma: Stop Stress Before It Becomes Disease! (Do THIS Before Every Meal)
Jay Shetty interviews nutritionist and wellness strategist Mona Sharma about her journey from corporate burnout, heart palpitations, and PCOS to healing through yoga, meditation, holistic nutrition, and nervous system work. Mona explains why she focuses on root causes rather than symptoms, emphasizing stress and nervous system dysregulation as precursors to disease. She shares practical tools like breathwork, visualization, heart coherence, and personalized morning routines to help people shift from chronic stress into a restorative state where true healing can occur.
The Mystery of the Sleepy Sickness
The hosts explore encephalitis lethargica, also known as the sleepy sickness, a mysterious early 20th-century epidemic that caused profound sleep disturbances, movement disorders, psychiatric changes, and often death. They explain von Economo's classification of acute and chronic forms, the later emergence of post-encephalitic parkinsonism, and how Oliver Sacks's work with L-DOPA inspired the book and film 'Awakenings.' The episode reviews competing theories about the disease's cause and transmission, modern autoimmune hypotheses, and the haunting experience of patients who were conscious yet immobile for decades.