Andrew Huberman interviews Dr. David Spiegel about hypnosis as a state of highly focused attention that can enhance control over mind and body rather than diminish it. They discuss the underlying brain networks involved in hypnosis, including changes in the dorsal anterior cingulate cortex, dorsolateral prefrontal cortex, insula, and posterior cingulate cortex, and how these changes support dissociation, cognitive flexibility, and altered bodily control. The conversation covers clinical applications such as stress reduction, sleep, pain management, phobias, trauma and PTSD treatment, hypnotizability assessment, the eye‑roll test, the role of breathing, and how hypnotic-like states show up in performance, children, and group settings.
Andrew Huberman interviews communication expert Matt Abrahams from Stanford Graduate School of Business about how to improve speaking and communication in public, online, and one-on-one contexts. They discuss why public speaking anxiety is so common, how to communicate more authentically, how to prepare and structure messages, and how to practice spontaneous speaking without memorizing scripts. The conversation includes specific tools for managing anxiety, reducing filler words, handling interruptions, using stories effectively, engaging different audiences, and building long-term communication skills through reflection and feedback.
Andrew Huberman and respiratory neuroscientist Dr. Jack Feldman discuss how breathing is generated and controlled by the brain, with emphasis on the pre-Bötzinger complex, the diaphragm, and the evolution of mammalian respiration. They explore physiological sighs, how breathing patterns influence emotional and cognitive states, rodent studies of slow breathing and fear, and potential mechanisms involving the vagus nerve, olfaction, and carbon dioxide regulation. In the latter part, they discuss magnesium threonate's effects on synaptic plasticity and cognitive aging, including animal and human data on learning, memory, and mild cognitive decline.
Psychic medium Laura Lynn Jackson returns to discuss how to move from merely noticing signs to actually living a guided life. She explains the concept of a "team of light," how intuition differs from the analytical "monkey mind," and how to work with signs, inner knowings, and everyday moments to feel supported, make decisions, and reframe past experiences. The conversation gives listeners practical ways to cultivate trust in their inner guidance, especially during periods of confusion, grief, or major life transitions.
The host shares seven small, immediately usable habits designed to reset your mind, regulate stress, and boost energy without overhauling your entire routine. He explains when to use each habit, how to practice it in under a few minutes, and why it works psychologically and biologically. Throughout, he emphasizes using micro-habits to create emotional regulation, presence, and better decision-making in everyday situations.
Mel Robbins explains the crucial difference between stress and overwhelm and why confusing the two can contribute to burnout. Drawing on insights from psychiatrist Dr. K and physician Dr. Aditi Noorakar, she outlines a four-step, science-based process: label whether you're stressed or overwhelmed, use a specific breathing technique to reset your nervous system, perform a "brain dump" to offload mental load, and deliberately add a small, chosen challenge to restore a sense of control. The episode emphasizes that stress and overwhelm are biological states, not personal failings, and shows how simple practices can help listeners feel clearer and more in control.
Jay Shetty interviews nutritionist and wellness strategist Mona Sharma about her journey from corporate burnout, heart palpitations, and PCOS to healing through yoga, meditation, holistic nutrition, and nervous system work. Mona explains why she focuses on root causes rather than symptoms, emphasizing stress and nervous system dysregulation as precursors to disease. She shares practical tools like breathwork, visualization, heart coherence, and personalized morning routines to help people shift from chronic stress into a restorative state where true healing can occur.
Host William interviews investor Arnold Vandenberg about his decades-long exploration of the subconscious mind, one-pointed attention, and flow states, drawing on examples from yogic practices, neuroscience, and extreme situations like concentration camps. Arnold explains how he has used focus, breathwork, self-hypnosis, affirmations, and character development to transform his health, athletic performance, investing career, and resilience in the face of adversity. He also shares his current investment positioning in an overvalued market, emphasizing commodities and capital preservation, and concludes with reflections on happiness, love, and overcoming selfishness.
Tim Ferriss interviews science journalist James Nestor about how everyday breathing habits profoundly affect health, sleep, mental performance, and athletic capacity. They discuss historical and modern breathwork practices, the dangers of mouth breathing and sleep-disordered breathing (especially in kids), and simple, low-cost ways to improve nasal breathing, sleep quality, and CO2 tolerance. Nestor also explores indoor CO2 levels and cognition, the emerging field of bioelectric medicine, breathing for athletes, and how he approached structuring and writing his bestselling book "Breath."
Andrew Huberman explains how the immune system works, outlining the three main defense layers: physical barriers like skin and mucus, the innate immune response, and the adaptive immune system that generates antibodies. He describes how sickness behavior arises via neural and blood-borne signals, then details specific nervous-system-based tools-sleep posture, a cyclic hyperventilation breathing protocol, mindset effects on dopamine, fascia-targeted electroacupuncture, and spirulina-that can reduce inflammation, support immune function, and potentially shorten illness duration.