Andrew Huberman and respiratory neuroscientist Dr. Jack Feldman discuss how breathing is generated and controlled by the brain, with emphasis on the pre-Bötzinger complex, the diaphragm, and the evolution of mammalian respiration. They explore physiological sighs, how breathing patterns influence emotional and cognitive states, rodent studies of slow breathing and fear, and potential mechanisms involving the vagus nerve, olfaction, and carbon dioxide regulation. In the latter part, they discuss magnesium threonate's effects on synaptic plasticity and cognitive aging, including animal and human data on learning, memory, and mild cognitive decline.
Andrew Huberman and Dr. Konstantina Stankovic discuss how the auditory system works from the ear to the brain, emphasizing its extraordinary sensitivity and importance for communication, emotion, and cognition. They cover causes and types of hearing loss, tinnitus, noise exposure thresholds, and practical strategies to protect hearing, including sound level limits, earplugs, and possibly magnesium intake. The conversation also explores links between hearing loss and dementia, cochlear implants, genetic and environmental contributors to hearing loss, inner ear regeneration research, and broader issues such as environmental noise pollution and sensory-driven brain plasticity.