Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Andrew Huberman and Dr. David Sinclair discuss aging as a disease, the role of the epigenome and information loss in driving aging, and how these processes connect to visible signs of aging and age-related diseases. They explore how fasting, blood sugar control, growth hormone, amino acids like leucine, exercise, and compounds such as NMN influence key longevity pathways including sirtuins, mTOR, and NAD. The conversation also covers iron and senescent cells, biomarkers such as CRP and HbA1c, fertility and reproductive aging in animal models, and the broader concept that aspects of aging can potentially be slowed or partially reversed.
Feel Better Now: Neurosurgeon Reveals the New Science of Healing Your Body & Stopping Pain Today
Mel Robbins speaks with neurosurgeon and CNN chief medical correspondent Dr. Sanjay Gupta about the new science of pain, why chronic pain develops, and how it can often be reduced or prevented. They explore how pain is generated in the brain, the role of factors like sleep, mood, stress, and prior pain experiences, and why movement, meditation, and other non-drug approaches can change the brain's pain circuits. Gupta shares research-backed strategies such as the MEAT protocol, virtual reality, nerve blocks, and pain journaling, along with his wife Rebecca's long journey with chronic pain, to offer hope and practical tools for listeners.
Essentials: Using Your Nervous System to Enhance Your Immune System
Andrew Huberman explains how the immune system works, outlining the three main defense layers: physical barriers like skin and mucus, the innate immune response, and the adaptive immune system that generates antibodies. He describes how sickness behavior arises via neural and blood-borne signals, then details specific nervous-system-based tools-sleep posture, a cyclic hyperventilation breathing protocol, mindset effects on dopamine, fascia-targeted electroacupuncture, and spirulina-that can reduce inflammation, support immune function, and potentially shorten illness duration.
The Insulin & Heart Doctor: The Fastest Way To Burn Dangerous Visceral Fat. This is How Insulin Is Quietly Clotting Your Blood! - Dr Pradip Jamnadas
Cardiologist Pradip Jamnadas explains how modern lifestyles drive heart disease through insulin resistance, visceral fat, chronic inflammation, and hidden factors like gut dysfunction, toxins, and mold. He describes how fasting, time‑restricted eating, targeted exercise, and gut repair can reduce visceral fat, lower inflammation, improve vascular health, and rebalance the autonomic nervous system. The conversation also covers LDL particle quality, the limitations and side effects of statins, practical diet guidance, vagus nerve "hacks", and his personal reflections on mortality and living in the present moment.