with Sanjay Gupta
Mel Robbins speaks with neurosurgeon and CNN chief medical correspondent Dr. Sanjay Gupta about the new science of pain, why chronic pain develops, and how it can often be reduced or prevented. They explore how pain is generated in the brain, the role of factors like sleep, mood, stress, and prior pain experiences, and why movement, meditation, and other non-drug approaches can change the brain's pain circuits. Gupta shares research-backed strategies such as the MEAT protocol, virtual reality, nerve blocks, and pain journaling, along with his wife Rebecca's long journey with chronic pain, to offer hope and practical tools for listeners.
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Actionable insights and wisdom you can apply to your business, career, and personal life.
Chronic pain is not just a lingering injury in a body part; it is a brain-based memory loop shaped by your entire life context-sleep, mood, stress, past pain, and more-so effective relief often requires addressing these broader factors, not just the hurting area.
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Movement and early mobilization after many injuries help the body complete its healing work and can reduce the risk of chronic pain, whereas excessive rest and inflammation-suppression may feel good short term but can prolong or entrench pain.
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Your expectations and attention can powerfully modulate pain through the brain's own endogenous opioid system-tools like meditation, virtual reality, and reframing can measurably reduce pain and unpleasantness without drugs.
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Pain journaling and detailed self-observation turn you from a passive sufferer into an active investigator, helping you and your clinicians identify triggers, effective strategies, and overlooked "baggage" like depression, anxiety, or poor sleep that need attention.
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Once serious structural problems are ruled out, fear of movement can itself become part of the pain loop, so learning that safe activity is not damaging-and then gradually increasing it-is essential to breaking the cycle.
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Addressing "baggage"-such as depression, anxiety, isolation, and chronic stress-is not a side issue but a central part of effective pain care, and involving mental health professionals can be as important as medications or procedures.
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Because neuroplasticity is neutral, repeatedly focusing on pain can strengthen pain circuits, while deliberately cultivating alternative experiences-relaxation, positive movement, absorbing activities-can help rewire the brain away from pain dominance.
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Episode Summary - Notes by Micah