The conversation focuses on the oral microbiome, particularly the role of specific bacteria such as Fusobacterium nucleatum in tumor growth and oral-systemic health links. Victoria explains how habits like sugar consumption, beverage choices, brushing techniques, and smoking affect oral bacteria, saliva, tooth decay, and gum disease. She also discusses safe approaches to teeth whitening, the use of probiotics for oral health, and practical strategies like proper brushing, flossing, and drinking through straws to protect teeth.
Andrew Huberman interviews physician-scientist Dr. David Fagenbaum about how many existing FDA-approved drugs can be repurposed to effectively treat diseases beyond their original indications. Drawing on his near-fatal battle with Castleman disease and the work of his nonprofit Every Cure, Fagenbaum explains systemic blind spots in medicine, gives concrete examples of successful drug repurposing, and outlines how patients can better advocate for themselves and navigate disease-specific networks. They also discuss the role of AI in mapping drug-disease relationships at scale, the neuroscience of hope and tenacity, and how Fagenbaum's personal story shapes his mission to ensure that no one misses out on a helpful drug that already exists.