Internal medicine physician and insulin-resistance specialist Dr. Annette Bosworth explains why she believes routinely generating ketones is central to preventing and reversing many chronic conditions. She discusses insulin's role in aging and disease, the practical steps of her "keto continuum" approach, measurement of glucose and ketones, and tools like sardine fasts and exogenous ketones to break through insulin resistance. She also shares case studies from her practice, the story of using a ketogenic diet alongside her mother's cancer care, and her own legal and political ordeal that tested her faith and resilience.
Tim Ferriss discusses his frameworks for learning quickly, choosing projects, and structuring life around relationships and energy rather than rigid long-term plans. He shares in depth about his history of childhood sexual abuse, severe depression, and near-suicide, and explains how he has used tools like psychedelic-assisted therapy, brain stimulation, and metabolic psychiatry to dramatically improve his mental health. The conversation also explores emerging bioelectric medicine, the importance of social connection, the pitfalls of modern dating, and practical practices like annual mini-retirements to sustain long-term well-being and productivity.
Tim Ferriss interviews Roblox founder and CEO David Bazuki about his family's multi‑year struggle with his son Matthew's severe bipolar disorder and how a medically supervised ketogenic diet produced dramatic improvements after many medications and hospitalizations. They discuss metabolic psychiatry, ketosis, continuous glucose and ketone monitoring, and how physiology can underpin mental health. The conversation then shifts to the origin and growth of Roblox, its user‑generated economy, safety and civility at scale, the role of AI in the platform's future, and David's own health routines and long‑term decision‑making as a public company CEO.