Tim Ferriss: 4 Science-Backed Tools That Rewired Decades of Childhood Trauma & Depression
Tim Ferriss discusses his frameworks for learning quickly, choosing projects, and structuring life around relationships and energy rather than rigid long-term plans. He shares in depth about his history of childhood sexual abuse, severe depression, and near-suicide, and explains how he has used tools like psychedelic-assisted therapy, brain stimulation, and metabolic psychiatry to dramatically improve his mental health. The conversation also explores emerging bioelectric medicine, the importance of social connection, the pitfalls of modern dating, and practical practices like annual mini-retirements to sustain long-term well-being and productivity.
Essentials: Erasing Fears & Traumas Using Modern Neuroscience
Andrew Huberman explains the neuroscience of fear, trauma, and post-traumatic stress, detailing the brain and body circuits that generate and maintain these states. He describes how the autonomic nervous system, HPA axis, and amygdala-based threat circuitry interact with memory and prefrontal narrative systems to create adaptive and maladaptive fear responses. The episode reviews behavioral therapies, drug-assisted psychotherapies, physiological breathing protocols, lifestyle factors, and certain supplements that can help extinguish and replace fearful and traumatic memories.
How to Make Yourself Unbreakable | DJ Shipley
Retired Navy SEAL and former Tier 1 operator DJ Shipley discusses how he structures his days to protect and improve his mental, physical, and spiritual health after years of high-risk combat deployments and severe injuries. He details his rigid morning and evening routines, his strength and conditioning approach with coach Vernon Griffith, and how psychedelic-assisted therapy with Ibogaine and 5-MeO-DMT helped him confront depression, addiction to prescription meds, and suicidality. Throughout, he shares stories from his SEAL career, the toll of loss and survivor's guilt, and his current mission to help veterans, first responders, and civilians develop unbreakable mindsets and bodies.
No. 1 Sugar Expert: 17 Seconds Of Pleasure Can Rewire Your Brain!
Dr. Robert Lustig explains how dopamine-driven behaviors and ultra-processed food, especially sugar, can create a "hostage brain" by rewiring reward pathways and degrading metabolic and brain health. He details mechanisms linking sugar, artificial sweeteners, mitochondrial dysfunction, and reactive oxygen species to Alzheimer's, cancer, depression, and other chronic diseases, while contrasting environmental versus genetic risk. The conversation also covers GLP-1 weight-loss drugs, vaccines and public health communication, loneliness, serotonin and oxytocin, practical strategies to reduce sugar and ultra-processed food, and emerging research on psychedelics and brain rewiring.
Atheist vs Christian vs Spiritual Thinker: The Paperclip Problem That Exposes Religion!
The host brings together three thinkers-an atheist/agnostic philosopher, a Christian apologist, and a Hindu-trained psychiatrist and spiritual practitioner-to explore why so many people today report a lack of meaning and purpose. They debate whether purpose is objective or purely subjective, how religion, spirituality, neuroscience, trauma, technology, and social conditions contribute to a "meaning crisis," and whether any worldview can adequately address deep suffering such as children dying of cancer. Alongside high-level philosophical disagreement, they also discuss concrete psychological tools and spiritual practices that can help individuals move from feeling lost to experiencing more direction and purpose in their own lives.
#611 - Louis C.K.
Theo Von talks with Louis C.K. about performing edgy stand-up in different kinds of venues, parenting, childhood neglect, race and taboo language, and the creative process behind Louis's novel "Ingram". They explore the American literary voice, the evolution of language, and broader cultural issues like polarization, social media addiction, and technology's physical footprint. A large part of the conversation centers on Louis's public downfall, his struggles with sex and pornography addiction, 12‑step recovery, and how confronting his own failures has reshaped his life, work, and friendship with Theo.