Andrew Huberman and obstetrician-gynecologist Dr. Thais Aliabadi discuss how PCOS and endometriosis-two leading causes of infertility-are massively underdiagnosed and frequently dismissed as "normal" women's issues. They explain diagnostic criteria, underlying biology such as hypothalamic-pituitary-ovarian axis disruption and insulin resistance, and treatment options including lifestyle, supplements, medications, and surgery. They also cover egg count testing, egg freezing, endometriosis pain management, perimenopause and menopause symptoms, breast cancer lifetime risk assessment, and the need for women to actively advocate for their own health within a flawed medical system.
Internal medicine physician and insulin-resistance specialist Dr. Annette Bosworth explains why she believes routinely generating ketones is central to preventing and reversing many chronic conditions. She discusses insulin's role in aging and disease, the practical steps of her "keto continuum" approach, measurement of glucose and ketones, and tools like sardine fasts and exogenous ketones to break through insulin resistance. She also shares case studies from her practice, the story of using a ketogenic diet alongside her mother's cancer care, and her own legal and political ordeal that tested her faith and resilience.
Host Jay Shetty speaks with physician and researcher Dr. Sara Szal about how hormones function as the body's messaging system, what hormonal imbalance looks like, and why stress and lifestyle are central drivers of issues like fatigue, weight gain, mood changes, and fertility challenges. They discuss cortisol, insulin, sex hormones, thyroid function, the impact of chronic stress and relationships, and practical ways to measure and rebalance hormones through testing, nutrition, sleep, stress management, and more informed choices about birth control. The conversation also covers life-stage hormone shifts, the risks and benefits of the birth control pill versus IUDs, natural family planning, and how integrating spirituality and self-awareness with medical science can prevent burnout and support healing.
The host and four women's health experts explore how female physiology, hormones, and life stages change the way women should approach exercise, nutrition, fasting, recovery, and sleep. They explain why most fitness and medical research based on men fails women, detail how the menstrual cycle and perimenopause affect training and metabolism, and outline practical protocols for strength training, cardio, bone health, and weight management. The conversation also addresses fertility, energy availability, environmental toxins, supplements, and the need for women to advocate for their own health throughout life.
The host convenes four female health experts from exercise physiology, fertility, OB/GYN menopause care, and orthopedics to discuss women's hormonal health across the lifespan. They cover research bias against women, differences between male and female physiology, menstrual cycles as a vital sign, PCOS and endometriosis, contraception, fertility planning, perimenopause and menopause, and the role of lifestyle and hormone therapy in long-term health. Throughout, they emphasize that missing or irregular periods, chronic inflammation, and insulin resistance are early warning signs and that women can and should advocate for better-informed care.