What Loneliness Does To Your Brain with Ben Rein
Neil deGrasse Tyson, Gary O'Reilly, and Chuck interview neuroscientist Ben Rein about what loneliness and social isolation do to the brain and body. They distinguish between objective isolation and the subjective feeling of loneliness, explain the stress and inflammatory pathways involved, and discuss how personality, aging, technology, and drugs like alcohol, painkillers, and MDMA affect social behavior and health. Rein also shares research on empathy, dogs and oxytocin, and practical ideas for rebuilding social connection in an increasingly automated world.
Judd Apatow: Fear of Rejection Holding You Back? THIS Trick Will Silence the Inner Critic & Help You Feel Confident to Create
Jay Shetty interviews Judd Apatow about his life in comedy, from his early days as a teenage interviewer of stand‑up comics to creating influential films and television shows. Apatow describes learning to treat failure as part of the path to success, developing his voice as a writer and director, and navigating ego, rejection, and collaboration in Hollywood. He also talks about parenting, long‑term marriage, therapy, meditation, psychedelics, and the importance of kindness, mentorship, and doing work that feels meaningful rather than merely successful.
#481 - Norman Ohler: Hitler, Nazis, Drugs, WW2, Blitzkrieg, LSD, MKUltra & CIA
Lex Fridman talks with writer Norman Ohler about his research on drug use in Nazi Germany, including methamphetamine in the Wehrmacht and opioids in Hitler's inner circle. They discuss how overlooked pharmaceutical and illicit substances shaped military campaigns like the Blitzkrieg, Hitler's declining leadership, and postwar CIA programs such as MKUltra. The conversation also explores German resistance within the Third Reich, Berlin's postwar drug and club culture, and Ohler's broader project on the role of psychoactive drugs across human history.