Andrew Huberman speaks with neuroscientist David Burson about how the nervous system creates perception, focusing on vision, color processing, circadian regulation, balance, and movement control. They explain how retinal circuits, melanopsin-containing ganglion cells, the vestibular system, cerebellum, midbrain, basal ganglia, and cortex interact to stabilize our view of the world and guide behavior. The conversation concludes with a striking example of cortical plasticity in a blind Braille reader whose visual cortex had been repurposed for touch.